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Updated: Jun 24, 2025
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鉴定与PANoptosis相关的基因作为甲状腺癌的预后指标
Diya Xie1, Liyong Huang1, Cheng Li1
1Department of General Surgery, First General Hospital of Fuzhou Affiliated of Fujian Medical University, Fuzhou, Fujian Province, China.
Heliyon
|June 7, 2024
概括
这项研究将与PANoptosis相关的基因 (PRDEGs) 与甲状腺癌 (THCA) 的预后联系起来. CASP6成为一个关键的生物标志物,显示THCA诊断和治疗的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 甲状腺癌 (THCA) 死亡率正在上升,需要新的预后标志物.
- 计划性细胞死亡 (PCD) 形式的PANoptosis影响癌症的进展,并与各种恶性瘤有关.
- 在THCA中,PANoptosis相关基因 (PRDEGs) 的预后作用在很大程度上仍未被探索.
研究的目的:
- 调查PRDEGs和THCA之间的关联.
- 确定PRDEGs作为THCA患者潜在的预后生物标志物.
- 评估CASP6作为THCA的诊断和预后指标.
主要方法:
- 利用基因表达总体 (GEO) 和癌症基因组图谱 (TCGA) 数据库来识别THCA中的PRDEG.
- 使用LASSO回归和Cox分析构建了一个预后模型.
- 通过人体蛋白质图谱,基因丰富分析和免疫组织化学验证了通过人体蛋白质图谱的验证结果.
主要成果:
- 一个由9个基因组成的LASSO模型确定了与THCA预后相关的显著PRDEG.
- 三种PRDEG与远程转移,淋巴结转移和瘤阶段有很强的联系.
- CASP6在临床阶段和高诊断疗效方面表现出显著的差异表达,并且在THCA组织中更丰富.
结论:
- 在THCA中,PRDEG具有预后价值,提供新的治疗途径.
- CASP6被确定为一个有前途的治疗标和THCA的新预后生物标志物.
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