Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Proteomics01:33

Proteomics

7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The first and second zinc finger domains from Poly-ADP-ribose polymerase 1 (PARP1) are modified by hydrogen sulfide.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry·2026
Same author

A Dinuclear Iron(II) Persulfide Complex Reacts with O<sub>2</sub> to Give Sulfite: Relevance to Persulfide Dioxygenases.

Journal of the American Chemical Society·2026
Same author

H<sub>2</sub>S-Mediated Persulfidation of the Classical Zinc Finger Protein Yin-Yang 1.

Biochemistry·2026
Same author

Efficient carbon-based CsPbI<sub>2</sub>Br perovskite solar cells achieved <i>via</i> coordination passivation by CS and CO of 4-(2-thioureido)benzoic acid.

Chemical communications (Cambridge, England)·2025
Same author

Zinc and RNA Binding Is Linked to the Conformational Flexibility of ZRANB2: A CCCC-Type Zinc Finger Protein.

Biochemistry·2024
Same author

Chemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for H<sub>2</sub>S Mediated Persulfidation.

Angewandte Chemie (International ed. in English)·2024

相关实验视频

Updated: Jun 24, 2025

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
07:55

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality

Published on: June 2, 2023

1.1K

采矿蛋白质用于指再硫化.

Haoju Li1, Andrew T Stoltzfus1, Sarah L J Michel1

  • 1Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy Baltimore MD 21201 USA smichel@rx.umaryland.edu.

RSC chemical biology
|June 7, 2024
PubMed
概括

硫化 (H2S) 通过再硫化改变指 (ZF) 蛋白质. 这种广泛的翻译后修改影响了各种真核生物种中的所有ZF类,影响了关键的细胞通路.

科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 蛋白质组学是指蛋白质组学.

背景情况:

  • 硫化 (H2S) 是一种内源性气传递物,通过透硫化参与细胞信号传递.
  • 指 (ZF) 蛋白质的特征是氨酸丰富的域,是已知的H2S介导修饰的目标.
  • 了解ZF持续硫化的流行和范围对于破译H2S信号通路至关重要.

研究的目的:

  • 系统地评估频率并确定细胞中经历持续硫化的指蛋白的类型.
  • 确定ZF在不同真核生物物种和ZF结构类中的化范围.

主要方法:

  • 采用了元分析方法,评估了来自16项独立研究的22个数据集.
  • 分析了硫化物特异性蛋白质组学数据,以确定ZF蛋白内修饰的氨酸残留物.
  • 基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 分析进行了路径丰富.

主要成果:

  • 在广泛的真核生物体中发现了透硫指蛋白,包括人类,小鼠,老鼠,植物和浮游生物.
  • 所有主要类型的指蛋白质,通过它们的氨酸和氨酸连接体集来定义,都被发现易受持续硫化.
  • 途径分析揭示了诸如无素依赖蛋白质代谢和病毒致癌等过程中的丰富性.

更多相关视频

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

38.7K
Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry
12:07

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

Published on: March 24, 2012

16.3K

相关实验视频

Last Updated: Jun 24, 2025

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
07:55

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality

Published on: June 2, 2023

1.1K
Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

38.7K
Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry
12:07

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

Published on: March 24, 2012

16.3K

结论:

  • 指蛋白化是一种广泛且显著的翻译后修饰 (PTM),影响着各种物种和所有ZF蛋白类型.
  • 酸固化在基本的细胞过程中起作用,包括蛋白质降解和涉及病毒致癌的途径.
  • 这些发现突出了ZF化作为细胞信号传递和功能中的关键调节机制.