10年脊椎和非脊椎骨折缓解的最佳双酸盐值
Samer M Alboun1, Eman Khreisat2, Zaid E Alawneh3
1Rehabilitation and Rheumatology, Jordanian Royal Medical Services, Amman, JOR.
Cureus
|June 7, 2024
概括
这项研究确定了约旦人双酸盐启动的最佳骨矿物质密度值. 将这些门量身定制为当地人口,可以改善骨质疏松症治疗方案.
科学领域:
- 骨质疏松症的研究研究.
- 药物治疗药物 药物治疗药物
- 骨矿物质密度 骨矿物质密度
背景情况:
- 骨质疏松症治疗的全球T-score标准可能不适用于所有人.
- 种族和地区差异可能会影响骨矿物质密度 (BMD) 值.
研究的目的:
- 确定理想的骨矿物质密度 (BMD) 门,以在约旦队列中启动双酸盐治疗.
- 建立适合当地人口的双酸盐处方国家协议.
主要方法:
- 对328名怀疑患有骨质疏松症的成年患者的回顾性分析.
- 使用骨折风险评估工具 (FRAX) 和后勤回归,ROC和灵敏度分析.
- 评估了骨质疏松症预后指标的敏感性,特异性和准确性.
主要成果:
- 在约旦患者中确定了0.775g/cm2的最佳BMD值,以启动双酸盐.
- 这一门显示出在10年内降低关节骨质疏松症风险的显著潜力 (敏感度78.6%,特异性88.46%).
- 这些发现表明,需要针对本地BMD指导方针,而不是全球标准.
结论:
- 区域或国家特定的BMD门值优于全球T-score标准,用于双酸盐的启动.
- 这种方法考虑了种族差异,并优化了骨质疏松症的管理.
- 制定一个量身定制的国家协议可以提高双酸盐药物治疗的有效性.
更多相关视频
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
8.2K
07:52Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research
Published on: December 1, 2023
1.7K
相关概念视频
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Fractures: Bone Repair
3.2K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.2K
Essential Minerals for Bone Health
3.9K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.9K
Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
