在患有多发性硬化症和阿尔茨海默病的老年人中比较认知概况:相似之处多于差异
Laura M Hancock1, Rachel Galioto1, Tasha Rhoads1
1Neurological Institute (LMH, RG, TR), Section of Neuropsychology; Mellen Center for Multiple Sclerosis (RG, DO); Department of Biomedical Engineering (KN), Lerner Research Institute, Cleveland Clinic, OH; Lou Ruvo Center for Brain Health (BL, JBM, LHH), Cleveland Clinic, Las Vegas; College of Osteopathic Medicine (BL), Touro University, Henderson, NV; and Lou Ruvo Center for Brain Health (KK), Cleveland Clinic, OH.
Neurology. Clinical practice
|June 7, 2024
概括
患有多发性硬化症 (MS) 的老年人认知障碍与阿尔茨海默病 (AD) 不同,特别是在记忆方面,MS影响皮质和皮质下功能. 在严重损伤阶段,区分MS和AD的认知影响变得不那么可靠.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 神经学 神经学
背景情况:
- 认知障碍影响多发性硬化症 (MS) 患者多达65%的人.
- 患有MS的老年人 (EwMS,60岁以上) 的认知问题尚未得到充分研究.
- 很少有研究将EwMS认知特征与其他神经退行性疾病进行比较.
研究的目的:
- 在EwMS中描述认知障碍.
- 将EwMS的认知概况与因可能的阿尔茨海默病 (AD) 而经历认知障碍的人进行比较.
主要方法:
- 克利夫兰诊所的观察研究.
- 组合了6组:认知正常,认知正常的MS,由于MS或AD的轻度/重大神经认知障碍.
- 在不同群体中比较认知测试表现,损伤率和特定的认知技能.
主要成果:
- 在所有障碍级别的记忆测试中,EwMS的表现优于AD患者.
- 多发性硬化和阿尔茨海默病之间的认知差异在轻度损伤方面显著,但在严重损伤方面基本消失.
- EwMS表现出皮质下和皮质下缺陷,与MS中典型的皮质下缺陷不同.
结论:
- 多发性硬化症的认知特征可能涉及皮质和皮质下功能.
- 在严重损伤阶段,区分MS和AD的认知影响是不那么可靠的.
- 需要进一步的研究来了解患有多发性硬化症的老年人的认知能力.
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