与儿童喘有关的饮食摄入量,抗氧化剂,矿物质和维生素:孟德尔的随机化研究
Liang Luo1, Guanglei Chen2, Yan Zhou1
1School of TCM Health Care, Leshan Vocational of Technical College, Leshan, Sicuan Province, China.
Frontiers in nutrition
|June 7, 2024
概括
儿童喘风险与饮食有关. 较低的糖摄入量可能会降低风险,而较高的脂肪,和维生素D摄入量可能会增加儿童喘风险.
科学领域:
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
- 儿童呼吸道疾病 儿童呼吸道疾病
背景情况:
- 关于饮食,营养素和儿童喘 (CA) 之间的关联存在有限且不一致的证据.
- 调查饮食因素和CA之间的因果关系对于了解疾病病因至关重要.
- 门德尔随机化 (MR) 提供了一个强大的方法来评估这些关系.
研究的目的:
- 系统地调查日常饮食摄入量,血清抗氧化剂,矿物质和维生素与儿童喘 (CA) 之间的因果关系.
- 澄清特定的饮食成分和营养水平在CA发展中的作用.
- 为预防和管理CA的潜在营养干预提供基于证据的见解.
主要方法:
- 使用了孟德尔随机化 (MR) 方法.
- 选择的饮食摄入因素 (碳水化合物,蛋白质,脂肪,糖) 和抗氧化剂,矿物质和维生素的血清水平作为工具变量.
- 利用来自FinnGen和GWAS目录数据库的遗传数据进行逆变量权衡 (IVW) 和灵敏度分析.
主要成果:
- 在糖摄入量和儿童喘 (CA) 风险之间发现了反向关联 (OR:0.71).
- 血清 (OR: 1.63),脂肪摄入量 (OR: 1.44) 和血清维生素D水平 (OR: 1.14) 与增加的癌症风险之间观察到积极的关联.
- 这些发现表明特定的饮食和营养因素因果关系地影响CA风险.
结论:
- 建立了饮食中的糖和脂肪摄入量,以及血清和维生素D水平与儿童喘之间的因果关系.
- 突出了特定饮食成分对CA发展的潜在影响.
- 建议进一步研究以阐明这些观察到的关联的潜在机制.
相关概念视频
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Asthma: Pathogenesis and Management
386
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
386
Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K


