在患有抑郁症的老年人群中,尿道金属与前列腺特异性抗原之间的关联:一个横截面研究
Liquan Ren1, Yue Zhang2, Jinyi Wu1,3
1Department of Public Health, Wuhan Fourth Hospital, Wuhan, China.
Frontiers in public health
|June 7, 2024
概括
尿路 (Be) 暴露与前列腺特异性抗原 (PSA) 水平升高有关,特别是在老年人中. 抑郁症可能会增加PSA水平与 (Cd) 暴露,保证监测.
科学领域:
- 环境健康 环境健康
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 毒理学 毒理学 毒理学
背景情况:
- 前列腺特异性抗原 (PSA) 是前列腺健康的关键生物标志物.
- 尿路中的金属暴露是影响PSA水平的潜在环境因素.
- 抑郁症,尿道金属和PSA之间的相互作用需要进一步调查.
研究的目的:
- 调查尿液金属水平与前列腺特异性抗原 (PSA) 之间的关联.
- 探索抑郁症对尿道金属和PSA之间的关系的影响.
- 分析各种人口和健康子组中的这些关系.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) (2001-2010) 中1901名参与者的数据.
- 采用渐进多重线性回归 (MLR) 和受限立方线 (RCS) 分析.
- 根据年龄,BMI和抑郁状态进行了子组分析.
主要成果:
- (Be) 在一般人群和老年人 (>60岁) 中显示出与PSA的剂量反应相关性.
- 超重个体 (BMI 25-30) 也表现出一个Be-PSA协会.
- 在抑郁症患者中, (Cd) 与PSA显著呈阳性剂量反应关系.
结论:
- 暴露需要PSA监测,特别是在老年人和超重个体.
- 患有抑郁症的患者暴露于可能会增加PSA,这凸显了男性增加监测的必要性.
- 这些发现强调了环境因素对前列腺健康和疾病管理的重要性.
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