特定挥发性有机化学物质暴露与心血管疾病风险之间的关联:NHANES的见解
Shaojie Han1,2, Min Xie3, Siyuan Cheng1,2
1The First Clinical Medical College, Jinan University, Guangzhou, China.
暴露于挥发性有机化合物 (VOC) 与心血管疾病 (CVD) 有关. 这项研究发现VOC代谢物与一般人群中心血管疾病风险之间存在显著的关联,突出了公共卫生方面的担忧.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管疾病流行病学
背景情况:
- 环境污染物越来越多地与心血管疾病 (CVD) 有关.
- 挥发性有机化学物质 (VOC) 对心血管疾病发展的具体影响需要进一步调查.
研究的目的:
- 评估一般人群中暴露于挥发性有机化学物质 (VOC) 和心血管疾病 (CVD) 之间的关联.
- 分析尿液中的VOC代谢物与心血管疾病患病率之间的关系.
主要方法:
- 使用2005-2018年国家健康和营养检查调查 (NHANES) 数据进行横截面分析.
- 后勤回归,贝叶斯核机回归 (BKMR) 和加权量子总和 (WQS) 回归被用于分析VOC代谢物与心血管疾病的关联.
- 检查了个人和混合物暴露的VOC和CVD结果之间的关联.
主要成果:
- 总VOC显示出与心血管疾病的积极关联 (p=0.025),独立于传统的风险因素.
- 随着总VOCs的高四分位数,观察到心血管疾病的几率增加.
- 特定的VOC包括亚克罗莱因,亚克利胺和异烯与心血管疾病有积极的关联.
- 混合物分析表明,当度超过第75个百分点时,VOCs具有显著的影响,其中CEMA,DHBMA和AMCC具有影响力.
结论:
- 挥发性有机化学物质 (VOC) 在多种分析模型中与心血管疾病 (CVD) 有显著的关联.
- 这些发现强调了了解VOC暴露及其在心血管疾病中的作用对公共卫生的重要性.
- 这项研究为未来的研究提供了关键的见解,这些研究是关于环境因素的,这些因素有助于心血管健康.
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