在乌干达坎帕拉的青少年女孩和年轻女性中,他们更喜欢新的生物医学HIV暴露前预防方法:一项混合方法研究
Yunia Mayanja1,2, Ivy Kayesu1, Onesmus Kamacooko3
1Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI & LSHTM) Uganda Research Unit, Entebbe, Uganda.
Frontiers in public health
|June 7, 2024
概括
乌干达的青少年女孩和年轻女性 (AGYW) 对艾滋病毒暴露前预防 (PrEP) 方法的偏好不同. 那些性风险较高的人更喜欢长期起作用的选择,如注射剂和植入物.
科学领域:
- 公共卫生 公共卫生
- 预防传染病 预防传染病
- 性健康 性的健康
背景情况:
- 东部和南部非洲的青少年女孩和年轻女性 (AGYW) 面临高艾滋病毒感染风险.
- 关于AGYW对新型暴露前预防方法 (PrEP) 的偏好存在有限的数据,包括潜在的未来艾滋病毒疫苗.
- 这项研究调查了乌干达坎帕拉的AGYW中PrEP方法的偏好.
研究的目的:
- 确定14-24岁高风险老年妇女对五种生物医学HIV PrEP方法的偏好:口服,注射,阴道环,植入物和HIV疫苗.
- 确定与偏好不同PrEP方法相关的因素.
- 通过定性采访了解这些偏好背后的原因.
主要方法:
- 一项混合方法研究,涉及265名高风险AGYW在乌干达坎帕拉.
- 参与者在说明他们最喜欢的方法之前,先接受了关于五种PrEP方法的教育.
- 多项逻辑回归分析了与方法偏好相关的因素,并对20名参与者进行了深入采访.
主要成果:
- 艾滋病毒疫苗是最喜欢的方法 (34.7%),其次是口服PrEP (25.7%),注射PrEP (24.9%),PrEP植入物 (13.6%) 和阴道环 (1.1%).
- 对注射和植入PrEP的偏好随着年龄的增长以及性风险较高的人 (例如,多个伴侣,性传播感染) 增加.
- 对于这些长效方法的偏好在与艾滋病毒感染者或未知状态的性伴侣的参与者中较低.
结论:
- AGYW表现出对生物医学PrEP的不同偏好,在性风险较高的人群中倾向于长效方法.
- 口服PrEP仍然是一个至关重要的选择,特别是对于那些与 HIV 状态不明或阳性伴侣的 AGYW.
- 未来的艾滋病毒预防策略应该考虑这些多样化的偏好,以提高AGYW的吸收和坚持.
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