缩模式在海马子区域及其关系的认知功能在纤维肌痛患者的轻度认知障碍
Yingming Long1, Xinyan Xie1, Yingwei Wang1
1Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Frontiers in neuroscience
|June 7, 2024
概括
带有轻度认知障碍的纤维肌痛患者表现出海马亚区域体积的减少,这与较差的认知功能有关. 这些大脑变化可能表明在纤维肌痛显著认知下降之前存在补偿机制.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 认知科学 认知科学
背景情况:
- 纤维肌痛 (FM) 与海马体体积的减少有关.
- 在FM中,海马亚区域缩的具体模式尚不清楚.
- 这些变化与认知功能之间的关系需要进一步研究.
研究的目的:
- 评估 FM 患者的海马亚区域体积,这些患者有或没有轻度认知障碍 (MCI).
- 探索海马亚区域性变化与FM认知功能之间的关联.
主要方法:
- 包括35名FM患者 (21名患有MCI,14名没有MCI) 和35名对照.
- 使用蒙特利尔认知评估 (MoCA) 评估认知功能.
- 使用FreeSurfer V.7.3.2和分析的相关性,量化了海马子区域的体积.
主要成果:
- 与对照组相比,患有MCI的FM患者在左/右CA1头部,分子层头部,GC-DG头部,CA4头部和左 Presubiculum头部表现出较小的体积.
- 左CA1头部和分子层头部缩与MCI的FM患者的执行功能,命名和注意力差异相关.
- 没有MCI的FM患者表现出类似或略大的海马亚区域体积,没有显著的认知相关性.
结论:
- 左CA1头部和分子层头部缩与患有MCI的FM患者的认知缺陷有关.
- 这些海马亚区域变化没有在没有MCI的FM患者中观察到.
- 研究结果表明,在FM患者的海马体亚区域内,可能存在潜在的补偿机制,这些患者的认知能力下降之前.
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