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在全关节整形术中使用他类药物:系统性审查

Soroush Baghdadi¹, Mazyar Babagoli², Mohammad Soleimani²

¹Pediatric Orthopedic Surgery Department, Montefiore Medical Center, New York, USA.

Annals of medicine and surgery (2012)

|June 7, 2024

概括

类药物可以减少关节动和妄等并发症在关节和膝关节置换患者. 有证据表明,它们也可能降低长期修复手术风险,而不会增加毒性.

科学领域:

整形外科手术整形外科手术
心脏病学心脏病学
药理学药理学是指药理学的学科.

背景情况:

越来越多的人对关节整形术 (THA) 和膝关节关节整形术 (TKA) 患者使用他激素越来越感兴趣.
潜在的好处包括改善结果和减少术后并发症.
一次系统性审查,以评估这种人群中斯塔丁的疗效和安全性.

研究的目的:

系统地审查现有的关于在THA和TKA中使用他类药物的证据.
评估关节置换患者的类固醇治疗相关的益处和并发症.
综合有关心脏,非心脏和长期结果的发现.

主要方法:

按照PRISMA指南进行系统的文献审查.
在PubMed,Embase,Scopus,Web of Science和Cochrane数据库中进行了搜索.
纳入标准侧重于报告他类药物对THA/TKA结果影响的研究.

主要成果:

包括18篇论文;主要是用异质数据进行的回顾性研究.
关于在全关节关节整形手术中使用他类药物的风险和益处的证据有限而多样化.
研究检查了外科手术期间的心脏,临床,脏,肺和胃肠道结局.

结论:

在外科手术期间使用的他类药物可以减少前不服用他类药物的患者心脏 (如心房) 和非心脏 (如) 的并发症.
没有观察到随着他类药物的使用而增加肌肉或肝脏毒性的风险.
低水平的证据表明,他类药物可能会降低修复手术和骨解的长期风险.

关键词:

史塔丁类药物是一种关节关节整形术 (joint arthroplasty) 是一个关节整形术.关节更换关节更换关节更换结果结果结果结果.整体关节整形术整体膝关节关节整形手术

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