在患有精神疾病的第一期患者中,同类氨酸水平
Ning Fan1, Wenxuan Zhao1, Yajun Yun1
1Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, China.
Frontiers in psychiatry
|June 7, 2024
概括
在首次精神病患者,特别是男性中,高水平的同类氨酸 (Hcy) 水平很常见. 这些发现表明,高homocysteinemia可能在精神疾病的发展中发挥作用.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生化学
- 精神病学是一个精神病学.
背景情况:
- 高水平的homocysteine (Hcy) 与精神疾病如精神分裂症,抑郁症和双相情感障碍有关.
- 在精神疾病中高homocysteinemia的确切作用仍然不清楚.
研究的目的:
- 为了研究精神病症状的精神病患者的血清Hcy水平.
- 确定Hcy水平与特定精神疾病之间的关联.
主要方法:
- 纳入了191名首发精神病患者 (精神分裂症,急性/暂时性精神病障碍,躁狂/精神病重度抑郁症) 和56名健康对照.
- 使用酶循环方法测量血清Hcy水平;高homocysteinemia被定义为Hcy>15μmol/L.
- 统计分析包括ANOVA,t测试和多变量线性回归.
主要成果:
- 首发精神病患者的Hcy水平明显高于健康对照组.
- 患有精神分裂症,急性/过渡性精神病障碍,精神病重度抑郁期的男性显示Hcy水平升高.
- 多变量回归表明男性患高homocysteinemia的风险增加.
结论:
- 血清Hcy水平升高在患有精神病症状的第一期患者中很普遍.
- 超homocysteinemia可能有助于这些精神疾病的发病.
- 在这个人群中,男性性别被确定为高血糖蛋白血症的危险因素.
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