巴基斯坦人口中胃潰瘍出血的危險因素和結果:單中心觀察研究
Nazish Butt1, Muhammad Tayyab Usmani2, Nimrah Mehak1
1Department of Gastroenterology, Jinnah Postgraduate Medical Centre, Karachi 75505, Sindh, Pakistan.
概括
巴基斯坦的胃潰瘍出血與抗血小板使用和再出血的高死亡率有關. 替代药物增加了再次出血的风险,突出了管理这种常见胃肠道问题的关键因素.
科学领域:
- 胃肠病学 胃肠病学
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 胃潰瘍疾病 (PUD) 是全球健康面臨的重大挑戰,儘管治療方面取得了進展,但患病率仍持續.
- 非类固醇抗炎药物 (NSAID) 的使用和Helicobacter pylori感染是导致PUD的关键因素,特别是在某些地区.
研究的目的:
- 对风险因素和与胃潰瘍疾病相关的上部胃肠道 (GI) 出血相关的结果进行全面分析.
- 为了调查这些因素,特别是在巴基斯坦人口中.
主要方法:
- 一项回顾性队列研究,涉及142名被诊断患有胃出血的患者.
- 数据收集包括人口统计,症状,住院时间,死亡率,再出血事件和通过上肠道内镜进行Forrest分类.
主要成果:
- 研究人口的平均年龄为53岁,其中68.3%是男性. 常见的症状包括血 (82.4%) 和上胃疼痛 (75.4%).
- 一周后的死亡率为10.6%,一个月后为14.8%. 再次出血发生在14.1%的24小时内,18.3%的7天内.
- 抗血小板药物的使用与死亡率增加相关,而替代药物与更高的再出血率有关. 使用NSAID与福雷斯特III类有关. 重新出血强烈预测死亡率.
结论:
- 抗血小板药物和再出血是PUD相关的上部肠道出血患者早期死亡的重要危险因素.
- 替代药物的使用与这种患者队列中早期再出血的风险增加有关.
相关概念视频
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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
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01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
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Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
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01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
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01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
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01:28Peptic Ulcer Disease II: Pathophysiology
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01:25Peptic Ulcer Disease V: Surgical Management and Nursing Care
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