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长非编码RNA SUMO1P3作为尿路生物标志物用于监测膀癌进展

Silvia Galbiati¹, Arianna Bettiga², Giorgia Colciago²

¹Complications of Diabetes Unit, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Frontiers in oncology

|June 7, 2024

概括

这项研究确定了两个长非编码RNAs (lncRNAs),SUMO1P3和UCA1,作为检测膀癌进展的有希望的尿液生物标志物. 它们与miR-320a的综合分析显示了改善膀癌诊断的巨大潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

膀癌 (BC) 的诊断和监测依赖于侵入性手术.
非编码RNAs (ncRNAs) 具有作为非侵入性生物标记物的潜力.
作为新的BC生物标志物,SUMO1P3和UCA1正在被研究.

研究的目的:

评估SUMO1P3和UCA1作为膀癌的尿路生物标志物.
评估他们区分不同BC阶段和等级的能力.
探索它们在监测BC进展方面的潜力.

主要方法:

对113名NMIBC和MIBC患者和对照者的回顾性研究.
评估尿液中的SUMO1P3和UCA1表达.
对生物标志物的性能进行接收器操作特征 (ROC) 曲线分析.
自动RNA提取和ddPCR分析.

主要成果:

尿液中的SUMO1P3和UCA1表达显著区分高等级BC与对照.
在高度BC患者中观察到降低的miR-320a水平.
该SUMO1P3/miR-320a比率显示出显著的诊断功率.
建立了RNA提取和ddPCR的自动化方法.

结论:

在高度BC患者的尿液中,lncRNA SUMO1P3的含量升高.
单独或与UCA1或miR-320a结合的SUMO1P3,显示出预测BC进展的潜力.
这些发现支持开发用于膀癌管理的非侵入性尿路生物标志物.

关键词:

这就是SUMO1P3P3P.膀癌的进展情况液体活检活检液体活检长非编码RNA是什么意思尿路生物标志物尿路生物标志物

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相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...