相关实验视频
Updated: Jun 24, 2025

07:44
A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
338
肺栓塞的流行病学,病因学和病理生理学
Catherine R Glazier1, Frank A Baciewicz2
1School of Medicine, University College Dublin, Dublin, Ireland.
概括
肺栓塞 (PE) 诊断正在上升,但由于改善的治疗方法和遵守指南,死亡率正在下降. 了解风险因素和病理生理学是改善静脉血栓塞栓症 (VTE) 患者结果的关键.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 血管医学 血管医学
背景情况:
- 在过去二十年中,肺栓塞 (PE) 发生率在全球范围内有所增加.
- 增加的PE率与计算机断层扫描肺血管造影的使用增加以及更高的并发症负担 (肥胖,恶性瘤,年龄) 相关联.
研究的目的:
- 分析PE发病率,死亡率和生存率的趋势.
- 审查静脉血栓栓塞 (VTE) 和急性PE的病理生理学和危险因素.
主要方法:
- 从北美,欧洲和亚洲的PE发病率和死亡率数据的时间趋势分析.
- 审查已确定的风险因素和VTE和PE的病理生理机制.
主要成果:
- 尽管诊断的增加,PE死亡率显示全球下降趋势.
- 改善的生存率与加强的准则遵守,风险分层和治疗策略有关.
- 关键的VTE风险因素包括血静止,高凝血,内皮损伤和炎症,通常源于下肢深静脉血栓形成.
结论:
- 降低PE死亡率表明,临床管理方面取得了有效进展.
- 由于肺动脉封闭而导致的右心室 (RV) 衰竭是急性PE不良结果的关键决定因素.
- 鉴于VTE的发病率日益增加,对VTE预防和管理的进一步研究至关重要.
相关概念视频
Pulmonary Hypertension: Classification and Pathogenesis
169
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
169
Pneumonia II: Pathophysiology
255
The pathophysiology of pneumonia involves the following steps:
255
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
Pneumonia III: Complications and Assessment
200
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
200
Pulmonary Tuberculosis II
217
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
217
COPD: Pathogenesis and Clinical Features
259
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
259

