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吸烟是否与急性山病的风险有关? 一个系统的审查和元分析
Yuelin Yu1, Peng Gao1, Lianke Xie2
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
High altitude medicine & biology
|June 7, 2024
概括
这次元分析发现,吸烟与急性山病 (AMS) 风险之间没有显著的关联. 由于高异质性和对吸烟暴露的数据有限,需要进一步研究.
科学领域:
- 高空疾病研究 高空疾病研究
- 环境和职业健康问题
背景情况:
- 吸烟和急性山病 (AMS) 之间的关系仍然存在争议.
- 需要进行系统审查,以澄清吸烟与AMS风险之间的关联.
研究的目的:
- 系统地审查和分析有关吸烟与AMS风险之间的联系的现有文献.
- 使用元分析量化吸烟者与非吸烟者的AMS风险.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行系统的文献搜索,截至2021年10月19日.
- 使用95%置信区间 (CI) 计算未调整和调整的相对风险 (RRs).
- 超回归和分层分析来探索异质性;使用漏斗图表进行出版偏差评估.
主要成果:
- 28篇文章 (31项研究) 被纳入了元分析.
- 吸烟者中AMS风险的聚合调整RR为0.87 (95%CI:0.77-0.99),表明没有显著影响.
- 观察到很高的异质性,可能与上升的高度和研究群体的性别组成有关.
结论:
- 这一元分析表明,吸烟不会显著影响急性山病的风险.
- 高异质性和有限的定量吸烟暴露数据需要仔细解释研究结果.
- 未来的研究应该提供详细的吸烟暴露信息,以更好地了解其在AMS中的作用.
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