密集的三氨醇乙胺注射疗法可以在广泛的食道内镜下粘膜解剖后高度预防狭窄
Kenichiro Okimoto1, Tomoaki Matsumura1, Naoki Akizue1
1Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan.
在食道内镜下粘膜解剖 (ESD) 后进行密集的三氨乙胺 (TA) 注射,可以预防狭窄. 这种方法减少了在患有广泛切除的患者内镜气球扩张 (EBD) 的需要.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 在瘤学瘤学.
背景情况:
- 消化管内镜下粘膜解剖 (ESD) 用于大型病变.
- 广泛的切除会增加食道狭窄的风险.
- 预防术后收缩对于患者的治疗结果至关重要.
研究的目的:
- 评估密集的氨乙胺 (TA) 注射在广泛的ESD后预防食道狭窄的有效性.
- 为了比较接受密集TA注射和接受标准护理的患者之间的结果.
主要方法:
- 对27名接受ESD治疗的患者进行了广泛的食道病变 (周围切除≥3/4) 的回顾性研究.
- 组A (n=7) 接受每周/两周一次的强化TA注射,直到愈.
- 在ESD后,B组 (n=20) 接受了较少或没有额外的TA注射.
主要成果:
- 狭窄率和需要内镜气球扩张 (EBD) 的比例在A组为0%,而在B组为5%.
- 组A需要显著更多的TA注射会 (中位数为8对1.5).
- 两组之间瘤长度或外围切割直径没有显著差异.
结论:
- 强化TA注射可能有助于预防ESD后狭窄和EBD,特别是经过广泛的外周切除后.
- 这一策略可以改善接受复杂食道ESD手术的患者的治疗结果.
- 需要进一步的前性研究来证实这些发现.
更多相关视频
09:40An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
Published on: April 17, 2020
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
相关概念视频
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Endoscopic Procedures I: Esophagogastroduodenoscopy
During an EGD, the endoscope can be used to:
Endotracheal Intubation I: Procedure
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
