对阿尔茨海默病诊断中的深度学习技术进行全面的审查
Anjali Mahavar1, Atul Patel1, Ashish Patel2
1Chandaben Mohanbhai Patel Institute of Computer Application, Charotar University of Science and Technology, CHARUSAT-Campus, Changa, 388421, Anand, Gujarat, India.
Current topics in medicinal chemistry
|June 7, 2024
概括
深度学习 (DL) 方法通过分析生物标志物显示出早期阿尔茨海默病 (AD) 诊断的前景. 本综述详细介绍了DL技术和数据集,以改善老年人AD检测.
科学领域:
- 神经学 神经学
- 人工智能的人工智能
- 生物医学工程 生物医学工程
背景情况:
- 阿尔茨海默病 (AD) 是一种进展性神经系统疾病,导致认知和身体衰退,主要影响老年人.
- 准确和早期诊断AD对于有效的管理和治疗至关重要.
- 机器学习,特别是深度学习 (DL),正在成为早期AD风险评估的强大工具.
研究的目的:
- 为深度学习 (DL) 方法提供全面的审查,以自动化早期阿尔茨海默氏症 (AD) 诊断.
- 探索在AD检测中使用的各种生物标志物和DL算法.
- 讨论ADNI和OASIS等数据集在AD研究中的实用性.
主要方法:
- 对应用到阿尔茨海默病 (AD) 诊断中的深度学习 (DL) 技术的文献综述.
- 阿尔茨海默病过渡性神经学 (ATN) 生物标志物的分类.
- 系统地描述DL算法,包括DNN,CNN,RNN,k-NN,DBM和DBN.
- 分析广泛使用的数据集,如ADNI和OASIS.
主要成果:
- 深度学习 (DL) 技术在自动化早期诊断阿尔茨海默病 (AD) 方面显示出巨大潜力.
- 各种DL算法和生物标志物正在用于早期AD评估.
- 性能指标,如AUC值和准确度,在不同的DL方法和数据集中有所不同.
结论:
- 深度学习 (DL) 为早期发现阿尔茨海默病 (AD) 提供了先进的功能.
- 需要进一步的研究和对DL技术的批判性评估,以提高诊断的准确性和有效性.
- 未来的趋势指向整合多样化的数据模式和改进DL算法,以改善AD预测.
相关概念视频
Alzheimer's Disease: Overview
462
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
462
Alzheimer's Disease: Treatment
179
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
179
Dementia
110
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
110


