同步原发性结核病和与EBV相关的原发性淋巴细胞癌
Anandhi Anbalagan1, Deepti Jain1, Senthil Kumar Ravichander2
1Department of Pathology, MIOT International Hospital, Manapakkam, Chennai, Tamil Nadu, India.
Indian journal of pathology & microbiology
|June 7, 2024
概括
这项案例研究突出显示了一次性淋巴细胞癌和肺结核在腺中的罕见并发现象. 早期诊断和适当的治疗,包括抗结核疗法,对于管理这种复杂的疾病至关重要.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 病理学 病理学 病理学
- 传染性疾病 传染性疾病
背景情况:
- 腺体质量可能会带来诊断挑战,差异包括恶性瘤和感染.
- 结核病虽然在南亚很常见,但却是发腺胀的不常见原因.
- 初级淋巴细胞癌 (PLEC) 是一种罕见的唾液腺恶性瘤,通常与爱斯坦-巴尔病毒 (EBV) 相关.
研究的目的:
- 报告一种独特的病例,该病例是在腺中同时存在的原发性淋巴细胞癌和结核病.
- 强调在虫群体的差异诊断中考虑结核病的重要性,特别是在流行地区.
- 讨论这种双重病理的诊断方法和管理.
主要方法:
- 进行了诊断性鼻腔内镜和视频喉强光镜检查.
- 使用正子发射断层扫描 (PET) 扫描来排除其他初级病变.
- 脊椎病变的外科切除,用于他的病理学检查.
- 结核病的聚合酶链反应 (PCR) 和EBV的现场杂交 (ISH) 在组织样本上进行.
主要成果:
- 组织病理学证实了原发性淋巴细胞癌.
- 结核病的PCR测试呈阳性,具有对利芬素敏感的耐药性.
- 对EBV的ISH测试呈阳性.
- 在PET扫描中没有发现其他原发性病变.
结论:
- 最终的诊断是原发性淋巴细胞癌与腺结核同时存在.
- 患者开始接受抗结核疗法.
- 这一案例强调了对状腺胀的广泛差异诊断的需要,并突出了恶性瘤和感染的罕见并发现象.
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