微生物代谢物通过重塑瘤微环境影响瘤进展,免疫力和治疗预测 (评论)
Yuhang Zhou1, Wenjie Han1, Yun Feng1
1Department of Breast Medicine 1, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, Liaoning 110042, P.R. China.
International journal of oncology
|June 7, 2024
概括
微生物代谢物影响瘤和免疫力,影响癌症的进展和治疗. 了解这些化合物为新的癌症疗法和改善患者治疗结果提供了潜力.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 代谢学 代谢学 代谢学
背景情况:
- 肠道和瘤微生物群影响癌症的发展.
- 微生物代谢产物在癌症的进展和免疫反应中起着关键作用.
- 代谢学研究强调了癌症患者和健康个体之间的差异.
研究的目的:
- 审查微生物代谢物在固体瘤中的作用.
- 检查它们对瘤免疫力和癌症治疗的影响.
- 列出用于癌症治疗的微生物代谢物的临床试验.
主要方法:
- 关于微生物代谢物和癌症现有研究的文献综述.
- 分析微生物代谢物对瘤免疫力和治疗疗效的影响.
- 对基于微生物代谢物的治疗方法的临床试验数据的汇编.
主要成果:
- 微生物代谢物影响瘤进展,免疫反应和治疗结果.
- 它们的影响可以是有益的或有害的,这取决于度和癌症类型.
- 代谢物可以调节免疫系统,信号通路和表观遗传修饰.
- 它们显示出缓解化疗/免疫治疗副作用和耐药性的潜力.
结论:
- 微生物代谢产物在微生物群与瘤相互作用中至关重要.
- 研究它们可以揭示新的补充癌症治疗方法.
- 这项研究可能会提高癌症治疗效率和患者预后.
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