Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

385
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
385
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

511
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
511
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

320
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
320
Antiepileptic Drugs: Calcium Channel Blockers01:17

Antiepileptic Drugs: Calcium Channel Blockers

371
Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
371
Arteries of the Lower Limbs01:24

Arteries of the Lower Limbs

188
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
188
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

286
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
286

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Anti-inflammatory potential of the CISACN adduct in LPS-induced murine models.

Inflammopharmacology·2026
Same author

Ribifolones A-H, New Macrocyclic Diterpenes from <i>Jatropha ribifolia</i>, Their Cytotoxic Activity and Insights Supported by Network Pharmacology and Molecular Modeling.

Molecules (Basel, Switzerland)·2026
Same author

Redox Disruption Induced by Saquayamycin B1 Promotes Cytotoxicity in Resistant Melanoma Cells.

ChemMedChem·2026
Same author

A Review of Pathophysiology and Computational Studies of Isoeugenol Derived Acetamides against Alzheimer's Disease.

Current topics in medicinal chemistry·2026
Same author

Tiliroside From Pavonia malacophylla (Link & Otto) Garcke as an Anti-SARS-CoV-2 Cell Entry Agent.

Chemistry & biodiversity·2026
Same author

Antinociceptive Effect of Cinnamaldehyde in Male Mice: Investigation of the Mechanisms of Action Through In Silico and In Vivo Approaches.

Chemistry & biodiversity·2026

相关实验视频

Updated: Jun 24, 2025

Electrophoretic Delivery of &#947;-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.0K

针对的多向烯类药物.

Teresa Carolliny Moreira Lustoza Rodrigues1, Arthur Lins Dias2, Aline Matilde Ferreira Dos Santos2

  • 1Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-900, João Pessoa, Paraíba, Brazil.

Current neuropharmacology
|June 7, 2024
PubMed
概括
此摘要是机器生成的。

研究人员探索了用于治疗的天然化合物. 一种类衍生物TR430通过与GABAA和AMPA受体相互作用,显示出有前途的多目标活性,这表明了症药物发现的新途径.

关键词:
这是一个AMPA.是一种病.这就是GABAAGABAA.分子对接的分子对接.多个目标的多重目标.基胺是一种基胺.

更多相关视频

Pentylenetetrazole-Induced Kindling Mouse Model
07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

33.0K
Planarian as an Animal Model for Experimental Acute Seizure
08:29

Planarian as an Animal Model for Experimental Acute Seizure

Published on: February 14, 2025

801

相关实验视频

Last Updated: Jun 24, 2025

Electrophoretic Delivery of &#947;-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.0K
Pentylenetetrazole-Induced Kindling Mouse Model
07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

33.0K
Planarian as an Animal Model for Experimental Acute Seizure
08:29

Planarian as an Animal Model for Experimental Acute Seizure

Published on: February 14, 2025

801

科学领域:

  • 药理学 药理学是指药理学的学科.
  • 神经科学是一个神经科学.
  • 自然产品 化学 化学

背景情况:

  • 是一种神经系统疾病,其特点是由于中枢神经系统 (CNS) 中的神经递质失衡而引起的反复发作.
  • 目前的抗药物往往有副作用,可能需要组合治疗,这突显了对新型治疗剂的需求.
  • 自然产品为发现具有潜在提高疗效和安全性概况的新药候选人提供了丰富的来源.

研究的目的:

  • 使用in silico方法研究类衍生物的潜在抗和多目标活性.
  • 为了确定可以调节发病因的关键标的新型天然化合物.
  • 评估有希望的候选分子的药理动力学和毒理学特性.

主要方法:

  • 468种类化合物的基于的虚拟查 (LBVS) 针对相关的标:AMPA,CaV,GABAA,GAT-1,KCNQ,NaV和NMDA.
  • 化合物的吸收,分布,新陈代谢,分泌和毒性 (ADMET) 分析,具有有利的LBVS结果.
  • 分子对接共识分析,以评估与验证目标的结合亲和力和相互作用.

主要成果:

  • 烯类衍生物TR430表现出优异的药理动力学特性,包括99.03%的口服吸收和遵守利宾斯基规则,没有观察到细胞毒性.
  • TR430与氨酸A (GABAA) 和α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) 受体都表现出显著的结合亲和力和相互作用.
  • TR430显示出多目标活性的潜力,作为GABAA激活剂和AMPA抑制剂,治疗中的关键机制.

结论:

  • TR430是一种有前途的天然化合物,具有潜在的多位抗活性.
  • 鉴定的化合物需要进一步研究其在治疗方面的治疗潜力.
  • 在神经系统疾病的自然产品库中发现新的候选药物时,in silico方法是有效的.