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Updated: Jun 24, 2025

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
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在无细胞合成生物学中基于机制和数据驱动的建模

Angelina Yurchenko1,2,3, Gökçe Özkul1,2,3, Natal A W van Riel4,5,6

  • 1Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands. t.f.a.d.greef@tue.nl.

Chemical communications (Cambridge, England)
|June 7, 2024
PubMed
概括

无细胞系统利用模拟合成生物学应用. 这一亮点回顾了用于设计合成遗传电路的基于机制和数据驱动的建模方面的进展.

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相关概念视频

Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
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