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Updated: Jun 24, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

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LNCHC直接结合并调节YBX1的稳定性,以改善与代谢功能障碍相关的脂肪性肝病进展

Kaikai Lu1, Xiaona Cheng1, Lei He1,2

  • 1Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Xi'an Jiaotong University Health Science Center, Xi'an, Shaan Xi, China.

Liver international : official journal of the International Association for the Study of the Liver
|June 7, 2024
PubMed
概括

这项研究揭示了长非编码RNA (lncRNA) LNCHC通过稳定YBX1来抑制与代谢功能障碍相关的脂肪性肝病 (MASLD),这反过来又调节PNPLA3以减少肝脂肪. 这为MASLD提供了新的治疗点.

关键词:
在LNCHC中,它是最重要的.这是一种PNPLA3蛋白.马斯尔德 马斯尔德是什么意思YBX1 一个字母.

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