在软组织肉瘤中UHRF1的表达和临床意义及其预后价值
Qiang Shu1, XiaoLing Liu2, Xing Xiang1
1Department of Hepatobiliary Surgery, Neijiang First People's Hospital affiliated to Chongqing Medical University, Neijiang, China.
Medicine
|June 7, 2024
概括
软组织肉瘤 (STS) 中高UHRF1基因表达与预后不佳相关,并影响瘤免疫微环境. 在STS患者中,UHRF1可以作为针对性治疗的预测标记.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 软组织肉瘤 (STS) 是一种多样化的恶性瘤群.
- 识别可靠的预后标志物和理解分子机制对于改善STS患者的治疗结果至关重要.
研究的目的:
- 研究软组织肉瘤中UHRF1基因的表达水平和预后意义.
- 探索UHRF1在STS中的分子机制和免疫微环境协会.
主要方法:
- 利用癌症基因组图谱 (TCGA) 数据库用于STS表达数据和临床病理参数.
- 分析了STS与邻近组织中的UHRF1表达,并将其与临床病理特征相关联.
- 进行生存分析,ROC曲线分析,GSEA和ssGSEA以评估预后价值和分子关联.
主要成果:
- 与相邻组织相比,在STS组织中,UHRF1的调节显著上升 (P < .001).
- 高UHRF1表达与较短的整体存活率 (OS) (P = .002) 相关,并与瘤坏死,组织学类型和转移相关.
- UHRF1表达被确定为STS预后的独立风险因素 (HR = 1.387,P = .044) 并与特定的信号通路和免疫细胞透模式有关.
结论:
- UHRF1在STS中高度表达,并作为一个重要的独立预后因素.
- 在STS中,UHRF1在调节瘤相关信号通路和免疫微环境方面发挥作用.
- UHRF1代表了一种潜在的分子标记物,用于预测软组织肉瘤的预后和向治疗.
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