胆酸概况和分类模型准确性用于炎症性肠病诊断
Run-Hao Xu1, Jia-Nan Shen1, Jing-Bo Lu1
1Department of Clinical Laboratory, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Medicine
|June 7, 2024
概括
血清胆酸分析可以帮助诊断炎症性肠病 (IBD). 特定的胆汁酸模式,如下次胆汁酸,区分IBD患者与健康个体以及其他肠道疾病患者.
科学领域:
- 胃肠病学 胃肠病学
- 代谢学 代谢学 代谢学
- 生物标志物发现发现
背景情况:
- 炎症性肠病 (IBD) 的诊断可能具有挑战性.
- 胆酸在肠道健康和疾病中起着至关重要的作用.
- 胆酸代谢的改变与胃肠道疾病有关.
研究的目的:
- 评估血清胆汁酸样本对炎症性肠病 (IBD) 的诊断效用.
- 为了识别与IBD相关的特定胆酸特征.
- 利用胆酸测量开发IBD诊断的预测模型.
主要方法:
- 分析了269名IBD患者,200名健康对照 (HC) 和174名其他肠道疾病 (OID) 患者的血清样本.
- 使用液体染色学-并联质谱法 (LC-MS/MS) 来量化15种特定的胆酸.
- 使用二进制物流回归和ROC曲线分析来评估诊断准确性.
主要成果:
- 与HC相比,IBD患者的几种二次胆酸 (例如,脱氧胆酸 - DCA) 含量显著降低,初级和二级胆酸比率升高.
- 一个结合DCA和陈氧胆酸 (CDCA) 的模型实现了0.866的AUC,以区分IBD和HC.
- 一个独立的模型,包括甘氨酸 (GCDCA),DCA和陶罗石醇酸 (TLCA),显示AUC为0.792以区分IBD与非IBD组.
结论:
- 在IBD患者中,血清胆汁酸概况发生变化,二次胆汁酸减少.
- 特定的胆酸特征与IBD发病有关.
- 结合特定胆酸的模型显示,有助于IBD诊断的潜力.
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