经过丰富的羊奶发酵 Lactobacillus paracasei 缓解抑郁心理障碍
Yuhan Sun1,2, Hongfan Zhao2, Mengjia Chang2
1College of Food Science and Technology, Northwest University, Xi'an, China.
Journal of food science
|June 7, 2024
概括
富含的发酵山羊奶,特别是Se-Lactobacillus paracasei 20241,有效地减少了小鼠模型中的抑郁行为. 这种益生菌干预还调节了炎症因素,氧化应激和肠道微生物群组成.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 营养科学 营养科学
背景情况:
- 抑郁症是一种广泛的精神疾病,治疗效果有限,副作用很大.
- 目前的抑郁症治疗面临挑战,原因是疾病的发展过程不可预测,患者的反应变化.
研究的目的:
- 使用Se-Lactobacillus paracasei 20241.1制备富含的发酵山羊奶.
- 在老鼠模型中研究这种丰富产品在慢性不可预测的压力诱导抑郁症中的抗抑郁机制.
主要方法:
- 用于丰富的发酵山羊奶的制备.
- 使用慢性不可预测压力 (CUMS) 在小鼠中诱导抑郁症.
- 评估抑郁行为,炎症标志物,葡萄糖皮质醇耐药性,氧化应激和肠道微生物群.
主要成果:
- 在CUMS小鼠中,Se-Lactobacillus paracasei 20241显著缓解了抑郁行为.
- 这项干预措施逆转了炎症因素的上调和减弱的葡萄皮质激素耐药性.
- 观察到对肝脏,海马体和前额皮层中氧化应激的调节效应,以及肠道微生物群组成的改变.
结论:
- 富含的发酵山羊奶在临床前模型中显示出抗抑郁药物的潜力.
- 该机制涉及对炎症,氧化应激和肠道微生物群的调节.
- 这为开发用于抑郁症管理的新型益生菌补充剂提供了基础.
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