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母亲与环境对小猪先驱微生物组的贡献

Landon K Eldridge¹, Dallas Soffa², Kyle J Hickman-Brown³

¹L Eldridge, Department of Animal Science, Texas A&M University, College Station, United States.

Reproduction & fertility

|June 7, 2024

概括

小猪开拓者微生物组主要是由分娩通道形成的,而不是生育箱或母乳. 出生期间的母因子显著影响新生儿早期的微生物殖民.

科学领域:

微生物学微生物学
动物科学动物科学
新生儿健康新生儿健康

背景情况:

先驱微生物组代表了新生儿最初的微生物殖民.
了解它的起源对于新生儿的健康和发育至关重要.

研究的目的:

量化母生和环境对小猪先驱微生物群的影响.
确定有助于小猪早期微生物建立的关键来源.

主要方法:

从黄金直肠,分娩通道,生育箱,小猪直肠 (0,3,10天,断奶) 和大奶中收集样本.
使用16S rRNA基因测序进行细菌DNA分析.
应用多重回归来评估微生物来源的贡献.

主要成果:

产道解释了小猪微生物组在第0天 (51.6%) 和第10天 (6.5%) 的显著变化.
小猪微生物组的组成和丰富性在第10天和断奶时发生了显著的变化.
生育箱和母乳细菌群落对小猪微生物组没有显著影响.

结论:

小猪先驱微生物组主要受到母亲的出生通道的影响.
在早期殖民化中,生育箱和母乳等环境因素起到较小的作用.
在分娩期间的母体微生物转移是新生儿肠道微生物群发育的关键决定因素.

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