科佩在预测非病理性术后多发性尿症时的实用性 在患有巨病的患者中,这些患者正在接受垂体神经外科手术
Emanuele Varaldo1, Nunzia Prencipe2, Alessandro Maria Berton2
1Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy. emanuele.varaldo@unito.it.
Pituitary
|June 7, 2024
概括
在接受神经外科手术的壮病患者中,早期的考佩评估可以预测术后多尿症. 这种生物标志物有助于识别患有流体平衡变化风险的患者,将其与中部无味糖尿病 (CDI) 患者区分开来.
科学领域:
- 内分泌学 在内分泌学.
- 神经外科 神经外科
- 生物标志物研究 生物标志物研究
背景情况:
- 平素是已知的预测器 中心糖尿病无味 (CDI) 后神经外科手术.
- 它在手术后监测壮症患者体液平衡变化的作用尚未得到充分证实.
研究的目的:
- 为了评估在经历神经外科手术的壮病患者中术后液体平衡的变化.
- 为了将这些变化与可佩和生长激素 (GH) 水平相关联.
- 为了探索copeptin在预测多尿症后壮症手术中的实用性.
主要方法:
- 一项针对15名经过内镜内切除的壮病患者的前性研究的二次分析.
- 每日液体平衡评估;手术前和手术后 (T0,T1,T2,T3) 测量可佩和GH的连续测量.
- 排除患有先前或神经外科术后CDI的患者.
主要成果:
- 11/15名患者在术后第二天体液平衡为负;4名患者出现多尿症.
- 术后的GH水平在多和非多组之间没有显著差异.
- 早期术后的可佩水平 (T1) > 39.9 pmol/L准确预测了多尿症 (灵敏度为100%,特异性为90.9%).
- 在多尿症患者中观察到较高的T1/T3平素比率;与壮症缓解相关的负流体平衡.
结论:
- 早期对可佩的评估可以识别患有积症的患者,这些患者在神经外科手术后面临多尿症的风险.
- 这可能有助于区分非病理性多尿症与CDI,指导临床管理.
- 平素作为一种有价值的工具,用于监测这种特定患者群体的液体平衡.
相关概念视频
01:15Hypoglycemia and Glucagon
256
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
256
01:30Acute Pancreatitis II: Clinical Manifestations and Management
118
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
118