术后输血和癌症进展:叙述性审查
Layal Abou Daher1, Olivia Heppell2, Ileana Lopez-Plaza3
1Department of Anesthesiology, Pain Management, & Perioperative Medicine, Henry Ford Health, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
Current oncology reports
|June 7, 2024
概括
术后输血可能会影响癌症的进展,影响因癌症类型而异. 虽然输血相关的免疫调节已有证据,但其在癌症手术中的临床意义需要进一步调查,因为自身输血显示出潜在的安全性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 输血医学 输血医学
背景情况:
- 术后输血在癌症手术中很常见.
- 人们对输血对癌症复发和进展的潜在影响存在担忧.
- 输血相关免疫调节 (TRIM) 是一个已知的现象.
研究的目的:
- 审查当前关于围绕术后输血和癌症进展的争议的证据.
- 评估血液管理和储存对TRIM的影响.
- 评估TRIM在癌症手术中的临床影响.
主要方法:
- 审查最近的实验室和临床证据.
- 在外科手术压力背景下研究TRIM的研究分析.
- 检查输血和癌症结局之间的疾病特异性关联.
主要成果:
- 实验室数据表明,TRIM可以通过血液处理来调节,但手术压力可能是一个更强的因素.
- 关于输血对癌症进展的独立影响的临床证据是混合的和癌症特异的.
- 自主输血似乎在癌症手术中是安全的.
- 需要前性数据来澄清现有关联.
结论:
- 术后输血对癌症进展的确切影响尚不清楚,可能是疾病特异性的.
- 虽然TRIM被记录在案,但它在癌症手术中的临床意义需要进一步研究.
- 在特定的癌症手术中,自身输血可能是一个更安全的替代方案.
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