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相关概念视频

Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Updated: Jun 24, 2025

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
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非编码RNAs 在牙周带干干细胞中的功能

Wei Zhai1, Jie Gao1, Wen Qin1

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, the Fourth Military Medical University, Xi'an, China.

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概括
此摘要是机器生成的。

非编码RNAs调节干细胞功能,影响牙周组织再生. 这些分子有望成为牙周病和正牙治疗的治疗点.

关键词:
机械应力 机械应力 机械应力没有编码的RNA.矯正牙科 矯正牙科是一種矯正牙科.牙周结节干细胞 牙周结节干细胞牙周病是指牙周病的发生.

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科学领域:

  • 分子生物学分子生物学
  • 干细胞生物学 干细胞生物学
  • 牙周医学 牙周医学

背景情况:

  • 非编码RNAs (ncRNAs) 是基本分子机制的关键调节者.
  • ncRNAs影响干细胞的自我更新,骨质生成,增殖和分化.
  • 牙周带干细胞 (PDLSCs) 对于牙周组织再生至关重要.

研究的目的:

  • 总结目前在PDLSC分子机制中对ncRNAs的研究.
  • 探索ncRNAs在PDLSC增殖和分化中的调控作用.
  • 使用ncRNAs识别牙周病的潜在治疗点.

主要方法:

  • 关于ncRNAs和PDLSCs研究的文献综述.
  • 对ncRNA参与干细胞自我更新和骨质生成的分析.
  • 在牙周组织再生中对ncRNA调节的研究.

主要成果:

  • ncRNAs显著影响干细胞自我更新和骨质生成.
  • ncRNAs调节PDLSC的增殖,并诱导骨的分化.
  • 在牙科学中,ncRNAs对PDLSC的增殖和分化产生调节作用.

结论:

  • ncRNAs在PDLSC生物学中发挥着至关重要的作用.
  • ncRNAs是牙周炎等牙周病的潜在治疗点.
  • 对PDLSCs中ncRNA的进一步研究可以推进牙周再生医学和正牙治疗.