酒精使用,情绪和双极性谱系障碍中的功能之间的纵向相互作用
Sarah H Sperry1,2, Audrey R Stromberg1,2, Victoria A Murphy2
1Department of Psychology, University of Michigan, Ann Arbor.
JAMA network open
|June 7, 2024
概括
酒精使用与情绪不稳定和双相情绪障碍 (BD) 中的工作功能不佳有关. 然而,BD中情绪症状恶化并不能预测未来的酒精使用,强调需要综合治疗.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 酒精使用障碍 (AUD) 经常与双相情感障碍 (BD) 发生,显著恶化患者的结果.
- 同时治疗BD和AUD的研究不足,在临床上被忽视,需要更深入地了解它们的相互作用.
- 在BD中描述酒精使用和情绪症状之间的动态关系对于改善患者护理和预后至关重要.
研究的目的:
- 在被诊断患有双相情感障碍 (BD) 的个人中调查纵向酒精使用模式.
- 检查酒精消费,情绪状态 (抑郁,躁狂/低躁狂),焦虑水平和随着时间推移的整体功能之间的时间联系.
- 为了确定这些因素如何在BD队列中纵向相互影响.
主要方法:
- 一项队列研究利用了来自双极性障碍普雷克特长度研究 (PLS-BD) 的数据.
- 纳入标准:诊断为双极性I (BDI) 或双极性II (BDII) 障碍,参与研究至少5年.
- 数据收集时间为2006年2月至2022年4月,随访时间为5年至16年. 标准化的评估测量了酒精使用,情绪症状,焦虑和功能.
主要成果:
- 在接下来的六个月中,有问题的酒精使用与抑郁和躁狂/躁狂症状的增加以及工作场所功能减弱相关.
- 相反,较高的抑郁或躁狂/躁狂症状并不能预测未来增加的酒精使用.
- 这些关联在双极 II 障碍中比双极 I 障碍更为明显. 随着时间的推移,酒精使用与焦虑水平没有显著的关联.
结论:
- 酒精使用,无论AUD诊断如何,都与BD患者的情绪不稳定和工作功能受损有关.
- 在BD中增加的情绪症状似乎不会导致随后的酒精使用.
- 在BD研究和临床实践中,对酒精使用的综合,维度和纵向评估和管理策略非常需要.
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