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相关概念视频

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
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酒精性心肌病:一个更新

Fernando Domínguez1,2, Eric Adler3, Pablo García-Pavía1,2

  • 1Department of Cardiology, Heart Failure and Inherited Cardiac Diseases Unit, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, CIBERCV, Manuel de Falla, 2, Majadahonda, Madrid 28222, Spain.

European heart journal
|June 7, 2024
PubMed
概括

酒精诱导心肌病 (AC) 是由于大量饮酒而导致的心脏损伤的结果. 禁欲是恢复的关键,为AC患者提供了很好的预后.

关键词:
酒精饮料 酒精饮料 酒精饮料 酒精饮料酒精性心肌病变性 酒精性心肌病变性病变的发生和发病.治疗方法 治疗方法

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科学领域:

  • 心脏病学 心脏病学
  • 毒理学 毒理学 毒理学
  • 遗传学 是一个遗传学.

背景情况:

  • 酒精诱导心肌病 (AC) 是一种与长期大量饮酒相关的心脏病.
  • 导致AC的精确酒精消费定义仍在争论中,尽管在5年内经常引用>80g/day.

研究的目的:

  • 审查酒精诱导心肌病变的发病原因.
  • 探索参与AC发展的机制,遗传因素和有助于条件.
  • 讨论AC的自然史和治疗策略,强调酒精戒断.

主要方法:

  • 本综述综合了有关酒精诱导心肌病的当前研究.
  • 它检查了乙醇及其代谢物乙甲对心肌的直接毒性影响.
  • 考虑了遗传性倾向,特别是titin-truncating变体,以及与其他疾病的协同效应.

主要成果:

  • 乙醇会诱导氧化应激,并激活氨酸-氨酸系统.
  • 乙甲通过影响actin-myosin相互作用并导致线粒体功能障碍而损害心脏功能.
  • 一个"双重打击"假设表明,AC源于遗传和环境 (酒精) 因素的结合.

结论:

  • 戒酒是AC最关键的干预措施,导致左心室喷射小部分的显著恢复和改善预后.
  • 虽然AC与其他扩张性心肌病有相似之处,但其过程受到戒酒的严重影响.
  • 未来的治疗可能会针对AC的特定病原性途径,可能会改善超出当前心力衰竭指南的结果.