基于社区的前性队列研究的结果有多普遍? 从成年人的思想变化研究扩展估计到其源人口
Laura E Gibbons1, Taylor Mobley2, Elizabeth Rose Mayeda2
1Department of Medicine, University of Washington, Seattle, WA, USA.
Journal of Alzheimer's disease : JAD
|June 7, 2024
概括
这项研究评估了成人思想变化 (ACT) 队列是否代表西雅图地区的老年人. 关于眼病和阿尔茨海默病风险的发现使用参与权重进行了概括.
科学领域:
- 老年学和流行病学.
- 眼科和神经病学 眼科和神经病学
背景情况:
- 成年人的思想变化 (ACT) 研究是来自凯泽永久华盛顿 (Kaiser Permanente Washington) 的长期老年人 (65岁以上) 队列,始于1994年.
- 评估ACT队列的代表性对于将研究结果推广到西雅图大都会地区更广泛的老年成人人口至关重要.
研究的目的:
- 评估ACT参与者代表西雅图地区所有老年人的表现.
- 确定ACT研究对眼睛疾病及其与阿尔茨海默氏症相关的研究结果对更广泛的老年成人人口的概括性.
主要方法:
- 利用来自ACT和行为风险因素监测系统 (BRFSS) 数据的聚合参与权重来估计疾病患病率和相关性.
- 雇佣的Cox比例危险模型,根据年龄,教育,吸烟,性别和APOE基因型进行调整.
- 引导信任区间以管理重量估计中的错误.
主要成果:
- ACT参与者与区域老年人普遍相似,在胆固醇药物使用和教育水平方面有显著差异.
- 参与者的体重对与年龄相关的黄斑变性和青光眼的患病率估计的影响很小.
- 与未加权数据相比,加权估计表明糖尿病视网膜病变和白内障史的患病率更高. 糖尿病视网膜病变和阿尔茨海默病风险之间的关联在加权数据中更强.
结论:
- 大多数眼睛疾病和阿尔茨海默病之间的关联在应用参与权重后仍然保持一致.
- 建议使用参与权重从社区群体评估更广泛的人口推断,即使观察到最初的相似之处.
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