复合物与NNN-Pincer配体用于使用甲醇对氨基的N-甲基化
Mengxuan Bai1, Shengxin Zhang1, Zhengguo Lin1
1Hebei Technology Innovation Center for Energy Conversion Materials and Devices, Hebei Key Laboratory of Organic Functional Molecules, College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, China.
新的复合物有效地利用甲醇催化氨酸N-甲基化. 配体上的电子捐赠的甲氧基团增强了催化活性,甲醇脱是决定速度的步骤.
科学领域:
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
- 有机合成 有机合成
背景情况:
- 鲁复合物是有机合成中的有价值的催化剂.
- 开发高效和选择性的N-甲基化方法对于合成氨酸至关重要.
研究的目的:
- 为了合成和描述新型的 (((II) NNN-pincer复合物.
- 为了评估它们在使用甲醇进行氨基的N-甲基化中的催化性能.
- 为了研究反应机制和连接物替代剂的影响.
主要方法:
- 合成与NNN-pincer连接体的鲁复合物 (Ru1-Ru4).
- 使用IR,NMR,HRMS和X射线晶体学进行表征.
- 用甲醇作为C1源和溶剂进行氨基N-甲基化中的催化试验.
主要成果:
- 复合物Ru1-Ru4的合成产量很好 (58-78%),并且显示出空气/水分稳定性.
- 这些复合物在N-甲基化中表现出高的催化效率和广泛的功能组耐受性.
- 复合Ru3,具有电子捐赠的OMe组,表现出最高的催化活性.
- 标签研究确定了甲醇脱化成化的甲醇脱化作为速度决定的步骤.
结论:
- 新型,稳定的 ((II) NNN-pincer复合物是氨酸N-甲基化有效的催化剂.
- 联体电子效应显著影响催化活性,电子捐赠组是有益的.
- 开发的协议提供了一种温和而有效的途径,用于使用CD3OD获得N-甲基化氨基和三化N-甲基胺.
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