在免疫功能受损的人群中,抗体和T细胞对同等增强剂SARS-CoV-2疫苗的反应:COVERALL-3研究
Alain Amstutz1,2,3, Frédérique Chammartin1, Annette Audigé4
1Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
The Journal of infectious diseases
|June 7, 2024
概括
双对应的mRNA疫苗在艾滋病毒或器官移植患者中产生了强烈的抗体反应. 接种疫苗后六个月抗体水平仍然很高,观察到罕见的不良事件.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 双对应的mRNA疫苗针对的是SARS-CoV-2变种.
- 在瑞士艾滋病毒和移植队列研究 (SHCS/STCS) 参与者中评估免疫反应.
- 对祖先和变种SARS-CoV-2菌株的评估反应.
研究的目的:
- 在免疫受损人群中评估对双价mRNA疫苗的免疫反应.
- 在接种疫苗后分析抗尖峰抗体和T细胞反应.
- 将艾滋病毒阳性患者和实体器官移植接受者之间的反应进行比较.
主要方法:
- 招募了接受双价mRNA疫苗的SHCS和STCS参与者.
- 在基线,4周,8周和6个月收集血液样本.
- 测量了抗抗体标位和T细胞反应.
主要成果:
- 高基线抗体响应在SHCS (87%) 和增加响应在STCS (58%至80%在6个月).
- 除肺移植患者外,所有参与者在4周后显示抗体增加了5倍.
- 在SHCS观察到强大的T细胞反应 (96%) 和STCS中适度增加 (36%到53%在6个月).
结论:
- 双对应的mRNA疫苗接种在艾滋病毒和移植患者中诱导了强烈的幽默免疫反应.
- 肺移植接受者表现出延迟的免疫反应.
- 6个月后,抗体水平仍然很高,不良事件的发生率很低.
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