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Bruna Dos Santos1, Rifat Farzan Nipun1, Anna Maria Subic1

  • 1Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

PLOS digital health
|June 7, 2024
PubMed
概括

虚拟阿片类药物中毒教育和纳洛分销 (OPEND) 计划有效地提高了对阿片类药物过量反应的知识和信心. 然而,访问仍然是一个挑战,大多数项目为城市环境中的白人提供服务.

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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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