一个由药剂师领导的跨专业药物坚持计划改善了口服抗癌疗法的坚持:OpTAT随机对照试验
Carole Bandiera1,2,3, Evelina Cardoso4, Isabella Locatelli3
1School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.
PloS one
|June 7, 2024
概括
一个由药剂师领导的坚持计划改善了在固体癌症患者中口服抗癌疗法 (PKI) 的药物实施. 虽然持久性和生活质量没有差异,但这种干预措施对提高治疗坚持有希望.
科学领域:
- 药理学和瘤学 药理学和瘤学
- 患者坚持的研究研究.
- 专业间医疗保健 专业间医疗保健
背景情况:
- 口服抗癌疗法,特别是蛋白激酶抑制剂 (PKIs),越来越多地用于癌症治疗.
- 评估改善患者遵守这些复杂口服药物的干预措施至关重要.
研究的目的:
- 评估药剂师领导的跨专业药物坚持计划 (IMAP) 对固体癌症患者PKI实施,持久性和坚持的影响.
- 评估该计划对患者对药物 (BAM) 和生活质量 (QoL) 的信念的影响.
主要方法:
- 118名患有固体癌症的患者被随机分配到干预组 (每月反的IMAP) 或对照组.
- 使用电子监视器 (EM) 监控PKI输送.
- 药物实施,坚持,持续性,BAM和QoL在12个月内进行了评估.
主要成果:
- 在6个月后,IMAP显著改善了干预组 (98.1%) 和对照组 (95.0%) 的日常PKI实施情况.
- 在药物持续性,对药物的信念或生活质量方面,没有观察到群体之间的显著差异.
- 该干预措施对男性,年轻患者 (<60岁) 和那些对坚持工具新手的患者显示出更大的益处.
结论:
- 药剂师领导的IMAP有效地支持在患有固体癌症的患者中用于PKI的药物实施.
- 虽然没有影响持续性或QOL,但改进实施是优化癌症治疗的关键一步.
- 将这种坚持干预措施纳入日常临床实践可能会提高无进展生存率.
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