在开普敦,为年轻夫妇制止艾滋病毒的多层次策略:对集群随机试验的研究协议
Wendee M Wechsberg1,2,3, Tara Carney4,5, Felicia A Browne1,2
1RTI International, Research Triangle Park, Durham, NC, United States of America.
PloS one
|June 7, 2024
概括
这项在开普敦的研究修改了夫妇健康合作社干预措施,包括艾滋病毒预防 (ART/PrEP),并与耻辱工作坊一起测试了其影响. 目标是改善年轻夫妇对艾滋病毒服务的接受和坚持.
科学领域:
- 公共卫生 公共卫生
- 预防艾滋病毒 预防艾滋病毒
- 基于社区的干预措施
背景情况:
- 年轻女性和男性在获得艾滋病毒预防服务方面面临重大障碍,包括耻辱和对抗逆转录病毒疗法/暴露前预防 (ART/PrEP) 的限制.
- 现有的干预措施需要调整,以有效地整合ART/PrEP,并解决与此同时出现的问题,如物质使用和基于性别的暴力.
研究的目的:
- 修改夫妇健康合作社 (CHC) 干预措施,包括ART/PrEP,创建CHC+.
- 评估一场关于社区对寻求艾滋病毒服务的个人态度的耻辱意识研讨会的影响.
- 测试CHC+在增加ART/PrEP启动和坚持方面的有效性,并减少物质使用,性风险和基于性别的暴力.
主要方法:
- 一个多层次的集群随机研究,涉及南非开普敦的24个社区.
- 将CHC干预修改为CHC+与社区和同行委员会投入.
- 用混合方法对480对夫妇的ART/PrEP启动,坚持和相关健康行为进行耻辱感意识研讨会和CHC+干预的评估.
主要成果:
- 目标1 (干预修改) 完成.
- 目标2,3和4正在进行中,评估了耻辱工作坊和CHC+对社区态度,ART/PrEP吸收,坚持和风险行为的影响.
结论:
- 结合减少耻辱的努力,CHC+干预措施有望改善高负担环境中的年轻夫妇的艾滋病毒预防和护理参与.
- 社区合作和严格的试验协议对于成功实施多层次社区卫生干预措施至关重要.
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