与艾滋病毒相关的免疫激活减弱了多功能IgG和B细胞对怀孕期间Tdap免疫的记忆反应
Martin Taton1, Fabienne Willems1, Cyprien Widomski2
1Institute for Medical Immunology and ULB Center for Research in Immunology (U-CRI), Faculty of Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium.
EBioMedicine
|June 7, 2024
概括
孕产妇感染艾滋病毒会削弱对Tdap疫苗的免疫反应,减少对新生儿转移的保护性抗体. 这可能会增加暴露于艾滋病毒的婴儿的百日咳风险.
科学领域:
- 免疫学 免疫学 免疫学
- 孕产妇健康 孕产妇健康
- 预防传染病 预防传染病
背景情况:
- 孕产妇接种Tdap疫苗可以保护新生儿免受 pertussis.
- 暴露于艾滋病毒的未感染婴儿 (HEU) 患上百日咳的风险更高.
- 孕产妇艾滋病毒对Tdap疫苗反应的影响尚不清楚.
研究的目的:
- 评估与艾滋病毒 (PWH) 感染的孕妇对Tdap疫苗接种的幽默免疫反应.
- 为了评估IgG水平,Fc依赖的效应器功能和B细胞 (MBC) 记忆反应.
- 为了确定艾滋病毒暴露的婴儿的IgG和狂热的胎盘转移.
主要方法:
- 观察性研究比较40名PWH和42名艾滋病毒未感染的孕妇.
- 测量了IgG水平,Fc依赖的效应器功能,以及Tdap疫苗接种前后的MBC频率.
- 在带血液中评估了IgG胎盘转移,狂热和免疫激活标记.
主要成果:
- 在接种疫苗后一个月,PWH显示MBC频率较低.
- 在分娩时,PWH已经降低了百日咳特异性的IgG水平和效应器功能.
- 与对照组相比,较低的母体IgG狂热度和多功能IgG转移到HEU婴儿.
结论:
- 孕产妇艾滋病毒感染与对Tdap疫苗接种免疫反应较弱有关.
- 降低对HEU婴儿的抗体转移可能会增加 pertussis 易感性.
- 免疫反应与母亲的可溶性CD14 (sCD14) 水平相关.
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