肺癌患者中的COVID-19:来自现实生活前性法国多中心研究的数据
O Molinier1, J Pinsolle2, A Bizieux Thaminy3
1Respiratory Medicine Department, Centre Hospitalier Le Mans, Le Mans, France.
Respiratory medicine and research
|June 7, 2024
概括
2020年,COVID-19对肺癌患者产生了重大影响,发病率很高. 这种病毒对他们的生存构成了重大威胁,突出了死亡率的关键风险因素.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 2020年初,COVID-19大流行开始,同时招募肺癌 (LC) 患者参加法国医院KBP-2020-CPHG前性队列研究.
- 这种时间重叠创造了在这个脆弱的患者群体中调查COVID-19的独特机会.
研究的目的:
- 为了确定肺癌患者中COVID-19的发病率.
- 在这个队列中确定与COVID-19感染和死亡率相关的风险因素.
- 评估COVID-19对肺癌患者预后的整体影响.
主要方法:
- 在疫苗可用之前收集了COVID-19数据.
- 对比了COVID-19阳性和阴性肺癌患者的临床特征.
- 分析了发生率比率,生存率 (1个月和3个月),以及COVID-19的预后影响.
主要成果:
- 2020年,在8,999名肺癌患者中,有285人被诊断出患有COVID-19,年发病率为8.3%.
- 在前吸烟者,状细胞或小细胞癌患者,高性能状态 (PS) 评分 (≥2) 和高级阶段 (III-IV) 中观察到更高的发病率.
- COVID-19显著增加了肺癌患者的死亡风险 (HR:4.12),年龄,LC阶段和PS得分被确定为主要死亡预测因素.
结论:
- 2020年期间,COVID-19在肺癌患者中呈现出高发病率.
- 在这个队列中,吸烟状况,癌症组织学,表现状况和阶段被确定为COVID-19的重要风险因素.
- COVID-19对肺癌患者的死亡率产生了重大不利影响.
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