可吸入的固体脂质纳米颗粒,用于潜在的结核病治疗
Pijush Kumar Paul1, Titpawan Nakpheng2, Himanshu Paliwal3
1Drug Delivery System Excellence Center, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand; Department of Pharmacy, Gono Bishwabidyalay (University), Dhaka 1344, Bangladesh; Faculty of Pharmacy, Universiti Sultan Zainal Abidin, Besut 22200, Terengganu, Malaysia.
International journal of pharmaceutics
|June 7, 2024
概括
新型纳米颗粒干粉吸入器 (DPI) 有效地将抗菌菌剂深入肺部用于结核病治疗. 这些配方显示出增强的疗效和降低药物度要求.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 肺部药物输送 肺部药物输送
背景情况:
- 通过纳米粒子系统通过肺部输送抗菌菌剂为结核病 (TB) 治疗提供了一个有前途的战略.
- 在开发保持纳米结构完整性和生物活性的干粉吸入器 (DPI) 方面存在挑战,用于深层肺沉积.
研究的目的:
- 开发和描述使用喷雾干燥用于有效的肺吸入治疗的DPI配制的含有levofloxacin的固体脂质纳米颗粒 (SLN).
- 评估开发的DPI配方的空气动力学特性,纳米结构的保存,细胞吸收和抗菌菌疗效.
主要方法:
- 用levofloxacin装载的SLN被制备并用喷雾干燥方法制成DPI.
- 用电子显微镜等技术评估粒子形态,尺寸和空气动力学特性.
- 对A549和NR8383细胞系进行了细胞吸收研究.
- 通过确定最小杀菌度 (MBC) 来评估对Mycobacterium bovis的抗菌活性.
主要成果:
- 喷雾干燥产生了尺寸缩小的微粒,保留了SLN纳米结构,并改善了气溶散射以深入肺透.
- 与非PEG化SLN相比,聚乙烯糖醇 (PEG) 修改配方显示细胞吸收增强.
- 服用莱沃素的SLN对Mycobacterium bovis的MBC (0.25微克/毫升) 显著较低,而不是自由的莱沃素 (1微克/毫升).
结论:
- 喷雾干燥的,含有levofloxacin的SLN配方适用于通过DPI通过肺部输送,保持纳米结构和生物活性.
- 这些基于纳米粒子的新型DPI显示出增强的抗菌菌疗效,表明改善结核病治疗的潜力.
- 基化可以进一步增强这些肺药物递送系统的细胞吸收.
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