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开发和药理学评估含有帕洛素化的脂质体和纳米囊

Raquel Chiarentin¹, Dienifer Pereira Bottcher², Bruna Zeni²

¹Bioanalysis Laboratory, Health Sciences Institute, Feevale University, Novo Hamburgo, RS, Brazil; Postgraduate Program in Toxicology and Analytical Toxicology, Feevale University, Novo Hamburgo, RS, Brazil.

International journal of pharmaceutics

|June 7, 2024

概括

纳米技术为治疗抑郁症提供了新的方法. 研究人员开发了脂质体和纳米囊与帕洛素化物,显示有希望的抗抑郁作用在小鼠减少不动时间.

科学领域:

药理学和纳米医学的研究.
神经科学和行为科学神经科学和行为科学

背景情况:

抑郁症是一种普遍的精神疾病.
纳米技术为增强药物输送和治疗疗效提供了机会.
帕洛西丁化是一种常见的抗抑郁药物.

研究的目的:

开发和描述含有帕洛素化物的脂质体和纳米囊.
在小鼠模型中评估这些纳米结构的抗抑郁药效应.
评估纳米载体的体外毒性和药物释放概况.

主要方法:

脂质体通过反相蒸发制备;纳米囊通过纳米沉制备.
特性包括粒子大小,多分散性指数,泽塔潜力,pH值,药物含量和关联效率.
使用开放场测试 (OFT) 和尾部悬浮试验 (TST) 评估的抗抑郁药类效应;在维罗细胞中评估的体外毒性.

主要成果:

纳米结构的颗粒大小从121.81到310.73nm,高联结效率 (98%),药物含量在80.82-94.36%之间.
与纳米囊 (95.59%) 相比,脂质体在10小时内释放帕洛素化的速度较慢 (43.82%).
这两种纳米结构在2.5mg/kg的TST中降低了不运动性,而不改变OFT交叉,表明抗抑郁作用. 纳米囊还通过减少理行为,显示出抗焦虑的效果.

结论:

开发的纳米结构有效地提供了帕洛胺化物,在低剂量下保留了其类似抗抑郁药的效果.
脂质体和纳米囊代表着帕洛素化的可行的纳米载体,可能改善抑郁症的治疗结果.
对基于纳米结构的抗抑郁药疗法的进一步研究是有必要的.

关键词:

脂质体是一种脂质体.严重的抑郁症严重的抑郁症纳米囊纳米囊纳米囊帕洛克西丁化药理学评价药理学评价

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