在22q11.2删除综合征和精神病症状中对大脑功能结构依赖的纵向分析
Silas Forrer1, Farnaz Delavari1, Corrado Sandini2
1Developmental Imaging and Psychopathology Laboratory, University of Geneva School of Medicine, Geneva, Switzerland; Medical Image Processing Laboratory, Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
概括
在22q11.2删除综合征 (22q11.2DS) 中,大脑功能结构依赖性 (FSDs) 的改变显示了从童年开始的发育偏差. 这些FSD变化在青春期恶化,特别是在那些有精神病症状的人群中,这表明潜在的早期干预目标.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 精神病学遗传学 精神病学遗传学
背景情况:
- 了解大脑功能结构依赖性 (FSDs) 对于评估神经机制至关重要.
- FSDs的典型和异常神经发育轨迹在很大程度上是未知的.
- 22q11.2删除综合征 (22q11.2DS) 为研究FSD发育和精神病的病理生理学提供了一个模型.
研究的目的:
- 调查22q11.2DS.DS的个体中FSD的发育轨迹.
- 检查FSD变化与精神病症状之间的关联.
- 确定22q11.2DS.中精神病风险的潜在早期生物标志物.
主要方法:
- 利用图形信号处理通过整合大脑活动和结构连接来量化FSD.
- 采用纵向多变量部分最小平方相关性来分析随时间变化的FSD.
- 评估了194个对照组和197个22q11.2DS载体 (7-34岁) 的391个静止状态功能和扩散权重的MRI扫描.
主要成果:
- 与对照组相比,患有22q11.2DS的个体从童年开始表现出持续的FSD发育偏移.
- 在22q11.2DS中,一个明显的发育模式在青春期显示出加剧的FSD变化,具有区域超和低合.
- 青少年FSD恶化与积极的精神病症状有显著的关联.
结论:
- 改变FSD成熟度在22q11.2DS.DS中青少年精神病的出现中起着关键作用.
- 在这项研究中发现的FSD偏差在精神病发作之前发生.
- 这些发现表明,FSD变化可能作为风险人群干预的早期指标.
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