介质细胞干细胞生物和生物技术的进步:临床应用的影响
Jana Pharoun1, Jana Berro1, Jeanine Sobh1
1Gilbert & Rose-Marie Chagoury School of Medicine, LAU, Byblos, Lebanon, P.O. Box 36.
European journal of pharmacology
|June 7, 2024
概括
介质细胞干细胞 (MSCs) 由于其分化和免疫调节能力,对各种疾病具有很大的治疗潜力. 需要进一步的研究来克服MSC治疗标准化和优化临床使用的挑战.
科学领域:
- 干细胞生物学 干细胞生物学
- 再生医学是一种再生医学.
- 免疫学 免疫学 免疫学
背景情况:
- 介质细胞干细胞 (MSC) 是多能细胞,具有分化成骨,软骨,肌肉和脂肪的潜力.
- MSCs具有免疫调节特性,为自身免疫和慢性退行性疾病提供治疗应用.
- 本综述涵盖了MSC的生物特性,应用,临床试验,制造,质量控制和临床挑战.
研究的目的:
- 审查介质干细胞的生物特性和治疗应用.
- 讨论与介质干细胞治疗相关的临床试验和挑战.
- 为MSCs提供有关制造条件和质量控制的见解.
主要方法:
- 使用PubMed,谷歌学者和Cochrane数据库进行了全面的文献审查.
- 包括2015年以来发表的论文,重点是MSC治疗的临床应用和研究.
- 考虑较旧的出版物作为该领域的基础研究.
主要成果:
- 骨髓衍生的MSCs是最受研究的,越来越多地使用脂肪和前皮衍生的MSCs.
- 对于COVID-19,缺血性中风,自身免疫性疾病,瘤和移植排斥,MSC疗法已被研究.
- 在MSC治疗中的挑战包括细胞存活率,免疫类型稳定性,效率和功能异质性.
结论:
- 介质细胞干细胞在各种疾病中具有显著的治疗前景.
- 进一步的研究是必要的,以充分实现MSCs的临床潜力.
- 解决标准化和优化挑战对于成功的临床翻译至关重要.
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