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Updated: Jun 24, 2025

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在老鼠中化物诱导的药物相互作用

Jingyu Zhang1, Weiwei Li1, Ying Liu1

  • 1State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics (J.Z., W.L., Y.L., Y.H., Z.C., X.L., Y.C., A.Z., J.Z.), School of Pharmacy (J.Z., W.L., Y.L., Y.H., Z.C., X.L., Y.C., A.Z., J.Z.), Guizhou Medical University, Guiyang, Guizhou, P. R. China; State Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, P. R. China (A.Z.); and Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China (Y.P., J.Z.).

Drug metabolism and disposition: the biological fate of chemicals
|June 7, 2024
PubMed
概括

在大鼠中,亚急性化物暴露显著降低了药物吸收和内部药物暴露. 这种肠道损伤,而不是P450酶的变化,可能会降低同时服用药物的有效性.

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