血陶可预测2型糖尿病患者的全因和因特定死亡率
Sylvia Liu1, Wai Kin Tham2,3, Janus Lee1
1Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore 768828.
The Journal of clinical endocrinology and metabolism
|June 7, 2024
概括
基于血陶的心血管事件风险测试 (CERT1) 评分预测了2型糖尿病患者的死亡风险. 这一分数提供了超越传统心风险因素的宝贵见解.
科学领域:
- 生物化学 生物化学
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 心血管事件风险测试 (CERT1) 评分,来自血陶,用于心血管风险评估.
- 了解血陶对2型糖尿病死亡率的预测价值至关重要.
研究的目的:
- 调查血陶能否预测被诊断为2型糖尿病患者的死亡风险.
- 在这个人群中评估CERT1得分的独立预测值.
主要方法:
- 一项涉及1903名新加坡2型糖尿病门诊患者的前性研究.
- 使用质谱测量测量了等离子体陶 (d18:1/16:0,d18:1/18:0,d18:1/24:0,d18:1/24:1).使用质谱测量进行测量.
- 计算了CERT1得分,并分析了与所有原因和特定原因死亡率的关联,平均9.3年.
主要成果:
- 与较低得分 (≤2) 相比,较高的CERT1得分 (≥7) 与所有死因死亡风险增加1.86倍,即使在调整心脏和脏因素后.
- 在CERT1得分上升1个单位与所有死因死亡风险上升8%相关.
- 将CERT1纳入RECODe死亡风险引擎改善了10年所有原因死亡率的预测.
- 在功能调整后,CERT1仍然与非心血管死亡有显著的关联,但与心血管死亡无关.
结论:
- CERT1评分独立预测2型糖尿病患者的死亡风险,超出已确定的心风险因素.
- 需要进行进一步的研究,以了解胺与死亡,特别是非心血管原因相关的机制.
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