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Updated: May 6, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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生物工程人类肠上的芯片用于推进非临床药物毒理学

Yong Cheol Shin1, Nam Than1, Soo Jin Park1

  • 1Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Expert opinion on drug metabolism & toxicology
|June 7, 2024
PubMed
概括

人体器官芯片模型,特别是肠芯片平台,为预测药物反应和毒性提供了传统非临床模型的有希望的替代方案.

关键词:
药物毒理学药物毒理学药物代谢 药物代谢药物-宿主-微生物群相互作用在芯片上的肠道.

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相关概念视频

iChip01:24

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
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