针对与羊的出生和断奶体重相关的直接和母性遗传效应的权重单步全基因组关联研究
Hava Khazaei-Koohpar1, Mohsen Gholizadeh2, Seyed Hasan Hafezian1
1Department of Animal Science and Fisheries, Sari Agricultural Sciences and Natural Resources University (SANRU), Sari, Iran.
Scientific reports
|June 7, 2024
概括
这项研究使用加权单步全基因组关联研究在Baluchi绵羊中确定了影响出生和断奶体重的关键基因组区域. 这些发现有助于用于改善绵羊肉生产的标记辅助选择.
科学领域:
- 动物遗传学动物遗传学
- 量化遗传学 量化遗传学
- 基因组学就是基因组学.
背景情况:
- 体重是羊肉生产的关键经济特征.
- 对体重特征的遗传改进是绵羊繁殖计划的主要目标.
- 识别与生长特征相关的基因组区域通过标记辅助选择加速繁殖.
研究的目的:
- 为了确定潜在的候选基因对直接和母性遗传影响出生体重 (BW) 和断奶体重 (WW) 在Baluchi羊.
- 通过加权单步全基因组关联研究 (WssGWAS) 精确确定与体重特征相关的基因组区域.
主要方法:
- 使用了权重单步全基因组关联研究 (WssGWAS).
- 分析了94只用Illumina 50K SNP BeadChip (54,241个标记) 基因组型的羊羔的基因组数据.
- 用1 Mb的基因组窗口来解释对BW和WW的直接和母性遗传影响的差异比例被计算出来.
主要成果:
- 顶级基因组区域解释了BW (4.30%直接,4.92%母性) 和WW (6.38%直接,5.76%母性) 的显著基因变异百分比.
- 特定的染色体 (例如,BW直接染色体的8个,BW母性染色体的10个,WW直接染色体和母性染色体的2个) 显示出对遗传变异的高贡献.
- 基因本体学分析确定了参与翻译,核酸结合和生长因子活性的候选基因.
结论:
- 该研究成功地确定了与Baluchi羊的出生和断奶体重相关的显著基因组区域.
- 这些发现为标记器辅助的选择提供了宝贵的遗传资源,以提高绵羊繁殖计划中的体重.
- 已识别的候选基因为羊的体重特征的遗传结构提供了洞察力.
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