结合治疗前的计算放射学,深度放射学和转录学,可以改善软组织肉瘤患者的预后
Amandine Crombé1,2,3, Carlo Lucchesi4, Frédéric Bertolo4
1Department of Oncologic Imaging, Bergonié Institute, F-33076, Bordeaux, France. amandine.crombe@chu-bordeaux.fr.
NPJ precision oncology
|June 7, 2024
概括
软组织肉瘤 (STS) MRI的放射学分析可以确定与预后相关的子组. 将放射学与基因表达结合起来,可以改善生存预测,揭示侵略性瘤中的炎症和缺氧途径.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 基因组学就是基因组学.
背景情况:
- 软组织肉瘤 (STS) 是一种异构的恶性瘤.
- 准确的预后对于治疗规划至关重要.
- 放射学为非侵入性瘤表征提供了潜力.
研究的目的:
- 用手工制作和深度放射学来识别软组织肉瘤 (STS) 亚组.
- 为了将放射学特征与组织病理学,基因表达和生存结果相关联.
- 评估放射学和转录学的综合预后价值.
主要方法:
- 手工制作的放射性特征 (h-RFs) 和深度放射性特征 (d-RFs) 从225名STS患者的对比度增强的MRI中提取.
- 深度放射学特征是使用卷积自编码器 (CAE) 和半监督CAE (HSCAE) 来得出的.
- 对110个样本进行了基因表达特征分析 (RNAseq);对放射学和RNAseq数据进行了无监督的聚类.
主要成果:
- 基于放射学的子组 (h-RFs,HSCAE) 与预后放射学特征和临床组织学等级相关,但与转录组没有直接关联.
- HSCAE和h-RF组与转移性复发无存活率 (MFS) 有关.
- 结合HSCAE和转录组显著改善了预后性能.
结论:
- 在治疗前,基于MRI的放射学可以识别具有临床和放射学相关性的STS子组.
- 将放射学与转录学相结合,可以提高STS的预后预测.
- 积极的STS亚组表现出高调的炎症,缺氧,亡和与差异化相关的基因.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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