在SARS-CoV-2疫苗接种个体中,肥胖,可能长期COVID的综合风险评分和睡眠问题之间的关联
Pei Xue1, Ilona Merikanto2, Eva A Delale3
1Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. pei.xue@uu.se.
International journal of obesity (2005)
|June 7, 2024
概括
在接种疫苗后,肥胖患者可能面临更高的长期COVID风险. 肥胖和可能的长期COVID都与睡眠障碍的增加有关,独立于体重指数.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 初步数据表明,肥胖可能会加速mRNA疫苗诱导的针对SARS-CoV-2的免疫力减弱.
- 肥胖对长期COVID接种疫苗后易感性的影响尚不清楚.
- 睡眠对免疫力至关重要,需要对其与肥胖和长期COVID相关的作用进行研究.
研究的目的:
- 为了探索肥胖,可能的长期COVID症状和接种疫苗的成年人睡眠障碍之间的联系.
- 为了确定肥胖是否会在SARS-CoV-2 mRNA疫苗接种后增加长期COVID的风险.
- 研究睡眠模式,肥胖和可能的长期COVID之间的关系.
主要方法:
- 对5919名接种疫苗的成年人 (18-89岁) 的调查数据的分析.
- 将体重归类为正常体重,超重和肥胖群体,使用特定种族的BMI截止值.
- 评估可能的长期COVID通过SARS-CoV-2 (PASC) 后急性后续的得分和睡眠模式通过问卷.
主要成果:
- 与正常体重相比,肥胖与可能的长期COVID (PASC分数≥12) 的更高几率比率 (1.55) 有显著关联.
- 在超重个体中,在可能的长期COVID风险中没有发现显著差异 (OR:0.92).
- 肥胖和可能的长期COVID都与增加的睡眠负担 (例如睡眠呼吸暂停,失眠) 独立相关 (P < 0.001).
结论:
- 接种疫苗后,肥胖的人可能有长期COVID-19症状的风险增加.
- 需要进行进一步的研究以严格确认感染 (例如,抗体测试).
- 可能的长期COVID和睡眠障碍之间的联系似乎独立于BMI.
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