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聚乙烯纳米颗粒触发了TDP-43的异常凝结,并引起了类似于肌缩性侧面硬化症的症状

Hang Sun^1,2, Bingwei Yang^1,2, Qiong Li²

¹State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.

Nature nanotechnology

|June 7, 2024

概括

纳米化聚烯塑料通过引起氧化应激和TDP-43蛋白聚合,引发类似ALS的症状. 这项研究揭示了环境污染与像ALS这样的神经退行性疾病之间的潜在联系.

科学领域:

环境科学环境科学
神经生物学神经生物学神经生物学
毒理学毒理学毒理学

背景情况:

肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病,影响运动神经元.
环境风险因素被怀疑是ALS病因,但机制尚不清楚.

研究的目的:

调查纳米尺寸聚烯塑料 (PS) 在诱导类似ALS的症状中的潜在作用.
阐明PS暴露可能导致神经退行症的分子机制.

主要方法:

在实验室中,细胞暴露于PS纳米粒子.
对氧化应激标记物和TDP-43蛋白聚合物的分析.
在和体内验证研究.

主要成果:

暴露于PS引起了细胞中的氧化应激和TDP-43聚合.
氧化的HSP70损害了TDP-43的核运输.
PS与细胞质TDP-43形成复合体,促进其聚合.

结论:

纳米化聚烯塑料可以通过一种新的毒理学机制诱导类似于ALS的病理.
研究结果表明,环境纳米颗粒污染与神经退行性疾病之间存在联系.

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